Drug interactions
Bendroflumethiazide + Empagliflozin-linagliptin
Severity: Moderate
Bendroflumethiazide and Empagliflozin-linagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Empagliflozin has a diuretic effect, and with a thiazide diuretic the risk of volume depletion, hypotension and dehydration rises. This matters most in elderly or renally impaired patients.
What this interaction means in plain words
Bendroflumethiazide and Empagliflozin-linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive osmotic and natriuretic diuresis causes greater volume depletion.
What to do
Assess volume status and blood pressure, monitor renal function and electrolytes, and consider reducing the diuretic dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-linagliptin
Frequently asked questions
Can I take Bendroflumethiazide with Empagliflozin-linagliptin?
MediHelp rates the interaction as moderate. Bendroflumethiazide and Empagliflozin-linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Empagliflozin has a diuretic effect, and with a thiazide diuretic the risk of volume depletion, hypotension and dehydration rises. This matters most in elderly or renally impaired patients.
How serious is the interaction between Bendroflumethiazide and Empagliflozin-linagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess volume status and blood pressure, monitor renal function and electrolytes, and consider reducing the diuretic dose if needed.
What other medicines interact with Empagliflozin-linagliptin?
MediHelp also lists interactions of Empagliflozin-linagliptin with, for example, Fosphenytoin, Rifampin, Rifapentine. The full list is on the Empagliflozin-linagliptin page.
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