Drug interactions
Bendroflumethiazide + Epinephrine
Severity: Moderate
Bendroflumethiazide and Epinephrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epinephrine shifts potassium into cells through beta2 stimulation, and thiazide diuretics cause renal potassium loss. Together they can produce additive hypokalemia, which raises the risk of ventricular arrhythmias, particularly with systemic or repeated epinephrine dosing.
What this interaction means in plain words
Bendroflumethiazide and Epinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Beta2-mediated cellular potassium uptake combined with thiazide-induced renal potassium wasting.
What to do
Check serum potassium and magnesium and replace deficits when epinephrine is used systemically in patients taking thiazides. Monitor ECG in patients with cardiac disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Bendroflumethiazide with Epinephrine?
MediHelp rates the interaction as moderate. Bendroflumethiazide and Epinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epinephrine shifts potassium into cells through beta2 stimulation, and thiazide diuretics cause renal potassium loss. Together they can produce additive hypokalemia, which raises the risk of ventricular arrhythmias, particularly with systemic or repeated epinephrine dosing.
How serious is the interaction between Bendroflumethiazide and Epinephrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and magnesium and replace deficits when epinephrine is used systemically in patients taking thiazides. Monitor ECG in patients with cardiac disease.
What other medicines interact with Epinephrine?
MediHelp also lists interactions of Epinephrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Epinephrine page.
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