Drug interactions
Bendroflumethiazide + Fenoprofen
Severity: Moderate
Bendroflumethiazide and Fenoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt the antihypertensive and diuretic effects of thiazides through sodium and water retention. The combination also raises the risk of acute kidney injury, especially in dehydrated or elderly patients. Potassium effects are variable and not the main concern.
What this interaction means in plain words
Bendroflumethiazide and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal blood flow and sodium excretion, antagonizing thiazide action.
What to do
Monitor blood pressure, fluid status, renal function and electrolytes, particularly at the start of therapy. Use the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Frequently asked questions
Can I take Bendroflumethiazide with Fenoprofen?
MediHelp rates the interaction as moderate. Bendroflumethiazide and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can blunt the antihypertensive and diuretic effects of thiazides through sodium and water retention. The combination also raises the risk of acute kidney injury, especially in dehydrated or elderly patients. Potassium effects are variable and not the main concern.
How serious is the interaction between Bendroflumethiazide and Fenoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status, renal function and electrolytes, particularly at the start of therapy. Use the lowest effective NSAID dose for the shortest time.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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