Drug interactions
Bendroflumethiazide + Hydrochlorothiazide-olmesartan
Severity: Moderate
Bendroflumethiazide and Hydrochlorothiazide-olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bendroflumethiazide duplicates the thiazide component already present, increasing diuresis, hypotension and risks of hypokalemia, hyponatremia, hyperuricemia and hyperglycemia. Olmesartan only partly offsets potassium loss.
What this interaction means in plain words
Bendroflumethiazide and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive inhibition of the distal tubular sodium-chloride cotransporter, causing additive electrolyte disturbances.
What to do
Avoid combining two thiazide-type diuretics unless intentionally planned. Monitor sodium, potassium and renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Frequently asked questions
Can I take Bendroflumethiazide with Hydrochlorothiazide-olmesartan?
MediHelp rates the interaction as moderate. Bendroflumethiazide and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bendroflumethiazide duplicates the thiazide component already present, increasing diuresis, hypotension and risks of hypokalemia, hyponatremia, hyperuricemia and hyperglycemia. Olmesartan only partly offsets potassium loss.
How serious is the interaction between Bendroflumethiazide and Hydrochlorothiazide-olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two thiazide-type diuretics unless intentionally planned. Monitor sodium, potassium and renal function.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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