Drug interactions
Bendroflumethiazide + Hydrocortisone
Severity: Moderate
Bendroflumethiazide and Hydrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics and corticosteroids both lower serum potassium. Used together they can produce hypokalemia, which may cause weakness, arrhythmias and increased digoxin toxicity.
What this interaction means in plain words
Bendroflumethiazide and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive renal potassium excretion from thiazide action on the distal tubule and corticosteroid mineralocorticoid effect.
What to do
Monitor serum potassium periodically, especially with high steroid doses or prolonged use. Supplement potassium or add a potassium-sparing agent if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Bendroflumethiazide with Hydrocortisone?
MediHelp rates the interaction as moderate. Bendroflumethiazide and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics and corticosteroids both lower serum potassium. Used together they can produce hypokalemia, which may cause weakness, arrhythmias and increased digoxin toxicity.
How serious is the interaction between Bendroflumethiazide and Hydrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium periodically, especially with high steroid doses or prolonged use. Supplement potassium or add a potassium-sparing agent if needed.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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