Drug interactions
Bendroflumethiazide + Indapamide
Severity: Moderate
Bendroflumethiazide and Indapamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two thiazide-type diuretics adds little antihypertensive benefit while increasing the risk of hypokalemia, hyponatremia and hypomagnesemia. This duplication is generally unnecessary.
What this interaction means in plain words
Bendroflumethiazide and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Both agents inhibit the sodium-chloride cotransporter in the distal tubule, producing additive urinary potassium and sodium loss.
What to do
Avoid therapeutic duplication and use only one thiazide-type diuretic. If both were given, check electrolytes and renal function promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indapamide
Frequently asked questions
Can I take Bendroflumethiazide with Indapamide?
MediHelp rates the interaction as moderate. Bendroflumethiazide and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining two thiazide-type diuretics adds little antihypertensive benefit while increasing the risk of hypokalemia, hyponatremia and hypomagnesemia. This duplication is generally unnecessary.
How serious is the interaction between Bendroflumethiazide and Indapamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid therapeutic duplication and use only one thiazide-type diuretic. If both were given, check electrolytes and renal function promptly.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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