Drug interactions
Bendroflumethiazide + Insulin lispro
Severity: Minor
Bendroflumethiazide and Insulin lispro: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can raise blood glucose and reduce the effect of insulin, mostly at higher doses. This may need an increase in insulin dose.
What this interaction means in plain words
Bendroflumethiazide and Insulin lispro have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Thiazides impair insulin secretion and sensitivity, partly via potassium depletion, opposing insulin action.
What to do
Monitor blood glucose and potassium when bendroflumethiazide is started or the dose raised. Increase the insulin dose if hyperglycemia develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin lispro
Frequently asked questions
Can I take Bendroflumethiazide with Insulin lispro?
MediHelp rates the interaction as minor. Bendroflumethiazide and Insulin lispro have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide diuretics can raise blood glucose and reduce the effect of insulin, mostly at higher doses. This may need an increase in insulin dose.
How serious is the interaction between Bendroflumethiazide and Insulin lispro?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and potassium when bendroflumethiazide is started or the dose raised. Increase the insulin dose if hyperglycemia develops.
What other medicines interact with Insulin lispro?
MediHelp also lists interactions of Insulin lispro with, for example, Alogliptin-pioglitazone, Ethanol, Metreleptin. The full list is on the Insulin lispro page.
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