Drug interactions
Bendroflumethiazide + Ketorolac
Severity: Moderate
Bendroflumethiazide and Ketorolac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs including ketorolac can reduce the diuretic and antihypertensive effects of thiazides and may increase the risk of acute kidney injury, especially in volume-depleted patients. The concern is mainly renal and blood pressure related rather than potassium related.
What this interaction means in plain words
Bendroflumethiazide and Ketorolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal prostaglandin synthesis causes sodium and water retention and reduced renal perfusion, opposing thiazide effects.
What to do
Monitor blood pressure, fluid status and renal function, and keep ketorolac use as short as possible. Maintain hydration and reassess the diuretic dose if the effect is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Frequently asked questions
Can I take Bendroflumethiazide with Ketorolac?
MediHelp rates the interaction as moderate. Bendroflumethiazide and Ketorolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs including ketorolac can reduce the diuretic and antihypertensive effects of thiazides and may increase the risk of acute kidney injury, especially in volume-depleted patients. The concern is mainly renal and blood pressure related rather than potassium related.
How serious is the interaction between Bendroflumethiazide and Ketorolac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status and renal function, and keep ketorolac use as short as possible. Maintain hydration and reassess the diuretic dose if the effect is lost.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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