Drug interactions
Bendroflumethiazide + Metformin-sitagliptin
Severity: Minor
Bendroflumethiazide and Metformin-sitagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can raise blood glucose, particularly at higher doses, and may reduce the effectiveness of antidiabetic therapy. At usual low antihypertensive doses the effect is generally modest.
What this interaction means in plain words
Bendroflumethiazide and Metformin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Thiazide-induced hypokalemia and reduced insulin secretion and peripheral glucose utilization antagonize antidiabetic effects.
What to do
Monitor glucose and HbA1c after starting or increasing the thiazide, and keep potassium in the normal range. Adjust the antidiabetic regimen if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-sitagliptin
Frequently asked questions
Can I take Bendroflumethiazide with Metformin-sitagliptin?
MediHelp rates the interaction as minor. Bendroflumethiazide and Metformin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide diuretics can raise blood glucose, particularly at higher doses, and may reduce the effectiveness of antidiabetic therapy. At usual low antihypertensive doses the effect is generally modest.
How serious is the interaction between Bendroflumethiazide and Metformin-sitagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c after starting or increasing the thiazide, and keep potassium in the normal range. Adjust the antidiabetic regimen if control worsens.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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