Drug interactions
Bendroflumethiazide + Olmesartan
Severity: Moderate
Bendroflumethiazide and Olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a thiazide with olmesartan lowers blood pressure more than either alone and offsets thiazide-induced potassium loss. Excess hypotension and renal function changes may occur, particularly in volume-depleted patients.
What this interaction means in plain words
Bendroflumethiazide and Olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antihypertensive effect, with ARB-induced potassium retention counteracting thiazide kaliuresis.
What to do
Monitor blood pressure, potassium, sodium and creatinine after starting or changing doses. Use lower starting doses in volume-depleted patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Frequently asked questions
Can I take Bendroflumethiazide with Olmesartan?
MediHelp rates the interaction as moderate. Bendroflumethiazide and Olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a thiazide with olmesartan lowers blood pressure more than either alone and offsets thiazide-induced potassium loss. Excess hypotension and renal function changes may occur, particularly in volume-depleted patients.
How serious is the interaction between Bendroflumethiazide and Olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, potassium, sodium and creatinine after starting or changing doses. Use lower starting doses in volume-depleted patients.
What other medicines interact with Olmesartan?
MediHelp also lists interactions of Olmesartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Olmesartan page.
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