Drug interactions
Benperidol + Buprenorphine
Severity: Moderate
Benperidol and Buprenorphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benperidol is a potent antipsychotic with sedative effects that can add to buprenorphine's CNS depression. Both drugs may also affect QT interval and cause hypotension.
What this interaction means in plain words
Benperidol and Buprenorphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, with possible additive QT prolongation.
What to do
Use the lowest effective doses, monitor sedation and respiratory status, and obtain an ECG if other QT risks exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buprenorphine
- Alvimopan + Buprenorphine Contraindicated
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Buprenorphine + Olanzapine / samidorphan Contraindicated
- Buprenorphine + Phenelzine Contraindicated
- Buprenorphine + Pimozide Contraindicated
- Buprenorphine + Thioridazine Contraindicated
Frequently asked questions
Can I take Benperidol with Buprenorphine?
MediHelp rates the interaction as moderate. Benperidol and Buprenorphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benperidol is a potent antipsychotic with sedative effects that can add to buprenorphine's CNS depression. Both drugs may also affect QT interval and cause hypotension.
How serious is the interaction between Benperidol and Buprenorphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses, monitor sedation and respiratory status, and obtain an ECG if other QT risks exist.
What other medicines interact with Buprenorphine?
MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan. The full list is on the Buprenorphine page.
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