Drug interactions
Benperidol + Butorphanol
Severity: Moderate
Benperidol and Butorphanol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benperidol is a potent antipsychotic, and with butorphanol it may cause additive sedation and hypotension. Respiratory depression is possible at higher doses.
What this interaction means in plain words
Benperidol and Butorphanol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from opioid agonism and antipsychotic receptor blockade.
What to do
Use lower initial butorphanol doses and monitor sedation and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Frequently asked questions
Can I take Benperidol with Butorphanol?
MediHelp rates the interaction as moderate. Benperidol and Butorphanol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benperidol is a potent antipsychotic, and with butorphanol it may cause additive sedation and hypotension. Respiratory depression is possible at higher doses.
How serious is the interaction between Benperidol and Butorphanol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use lower initial butorphanol doses and monitor sedation and blood pressure.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
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