Drug interactions
Benperidol + Clemastine
Severity: Moderate
Benperidol and Clemastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so together they can cause more drowsiness and slowed reactions than either alone. Both also have anticholinergic activity, which can worsen dry mouth, constipation and confusion in older patients.
What this interaction means in plain words
Benperidol and Clemastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through histamine H1 blockade and dopamine antagonism, with additive anticholinergic effects.
What to do
Start with low doses and monitor for oversedation and anticholinergic effects. Advise the patient against driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Benperidol and Clemastine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Clemastine
Frequently asked questions
Can I take Benperidol with Clemastine?
MediHelp rates the interaction as moderate. Benperidol and Clemastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so together they can cause more drowsiness and slowed reactions than either alone. Both also have anticholinergic activity, which can worsen dry mouth, constipation and confusion in older patients.
How serious is the interaction between Benperidol and Clemastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low doses and monitor for oversedation and anticholinergic effects. Advise the patient against driving until the response is known.
What other medicines interact with Clemastine?
MediHelp also lists interactions of Clemastine with, for example, Alfentanil, Benzhydrocodone / acetaminophen, Buprenorphine buccal. The full list is on the Clemastine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
