Drug interactions
Benperidol + Dextroamphetamine
Severity: Moderate
Benperidol and Dextroamphetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dextroamphetamine and antipsychotics have opposing dopaminergic effects. Benperidol blocks dopamine D2 receptors and may reduce the effect of the stimulant, while amphetamine may worsen psychosis. Sedation from benperidol may be partly offset.
What this interaction means in plain words
Benperidol and Dextroamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism between amphetamine-induced dopamine release and D2 receptor blockade by benperidol.
What to do
Monitor psychotic symptoms and the efficacy of both drugs. Avoid the combination in patients with psychotic disorders when possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Benperidol with Dextroamphetamine?
MediHelp rates the interaction as moderate. Benperidol and Dextroamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dextroamphetamine and antipsychotics have opposing dopaminergic effects. Benperidol blocks dopamine D2 receptors and may reduce the effect of the stimulant, while amphetamine may worsen psychosis. Sedation from benperidol may be partly offset.
How serious is the interaction between Benperidol and Dextroamphetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor psychotic symptoms and the efficacy of both drugs. Avoid the combination in patients with psychotic disorders when possible.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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