Drug interactions
Benperidol + Esketamine
Severity: Moderate
Benperidol and Esketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benperidol is a potent butyrophenone antipsychotic with sedative properties. With esketamine, sedation and psychomotor impairment may increase, and dissociative or psychotic symptoms may be affected.
What this interaction means in plain words
Benperidol and Esketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through pharmacodynamic effects.
What to do
Monitor sedation and mental status after esketamine dosing and review the benperidol dose if oversedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Frequently asked questions
Can I take Benperidol with Esketamine?
MediHelp rates the interaction as moderate. Benperidol and Esketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benperidol is a potent butyrophenone antipsychotic with sedative properties. With esketamine, sedation and psychomotor impairment may increase, and dissociative or psychotic symptoms may be affected.
How serious is the interaction between Benperidol and Esketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and mental status after esketamine dosing and review the benperidol dose if oversedation occurs.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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