Drug interactions
Benperidol + Ketamine
Severity: Moderate
Benperidol and Ketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benperidol is a potent butyrophenone antipsychotic; with ketamine it can increase sedation and hypotension. Both may affect cardiac conduction or blood pressure.
What this interaction means in plain words
Benperidol and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and dopamine and alpha-adrenergic blockade.
What to do
Titrate ketamine cautiously and monitor sedation, blood pressure and ECG if other QT-prolonging drugs are used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketamine
Frequently asked questions
Can I take Benperidol with Ketamine?
MediHelp rates the interaction as moderate. Benperidol and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benperidol is a potent butyrophenone antipsychotic; with ketamine it can increase sedation and hypotension. Both may affect cardiac conduction or blood pressure.
How serious is the interaction between Benperidol and Ketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate ketamine cautiously and monitor sedation, blood pressure and ECG if other QT-prolonging drugs are used.
What other medicines interact with Ketamine?
MediHelp also lists interactions of Ketamine with, for example, Benzhydrocodone / acetaminophen, Brexanolone, Buprenorphine buccal. The full list is on the Ketamine page.
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