Drug interactions
Benperidol + Meclizine
Severity: Moderate
Benperidol and Meclizine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are sedating, and meclizine adds anticholinergic effects to those of benperidol. This may cause drowsiness, dry mouth, constipation, urinary retention and confusion.
What this interaction means in plain words
Benperidol and Meclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and antimuscarinic effects.
What to do
Monitor for oversedation and anticholinergic effects. Avoid or minimise meclizine in elderly patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meclizine
Frequently asked questions
Can I take Benperidol with Meclizine?
MediHelp rates the interaction as moderate. Benperidol and Meclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are sedating, and meclizine adds anticholinergic effects to those of benperidol. This may cause drowsiness, dry mouth, constipation, urinary retention and confusion.
How serious is the interaction between Benperidol and Meclizine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and anticholinergic effects. Avoid or minimise meclizine in elderly patients.
What other medicines interact with Meclizine?
MediHelp also lists interactions of Meclizine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Meclizine page.
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