Drug interactions
Benperidol + Topiramate
Severity: Moderate
Benperidol and Topiramate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benperidol is a sedating butyrophenone antipsychotic, and topiramate can add drowsiness and cognitive slowing. The combination may increase sedation and impair concentration and coordination.
What this interaction means in plain words
Benperidol and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic CNS depression.
What to do
Monitor for sedation and cognitive effects when starting or adjusting either drug. Reduce the dose if drowsiness interferes with function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Topiramate
Frequently asked questions
Can I take Benperidol with Topiramate?
MediHelp rates the interaction as moderate. Benperidol and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benperidol is a sedating butyrophenone antipsychotic, and topiramate can add drowsiness and cognitive slowing. The combination may increase sedation and impair concentration and coordination.
How serious is the interaction between Benperidol and Topiramate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and cognitive effects when starting or adjusting either drug. Reduce the dose if drowsiness interferes with function.
What other medicines interact with Topiramate?
MediHelp also lists interactions of Topiramate with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Topiramate page.
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