Drug interactions
Benzhydrocodone / acetaminophen + Carbidopa-entacapone-levodopa
Severity: Moderate
Benzhydrocodone / acetaminophen and Carbidopa-entacapone-levodopa: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids can cause sedation and orthostatic hypotension, and levodopa can add somnolence and hypotension. Constipation from opioids may also reduce levodopa absorption.
What this interaction means in plain words
Benzhydrocodone / acetaminophen and Carbidopa-entacapone-levodopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant and hypotensive effects.
What to do
Use the lowest effective opioid dose and monitor for sedation and orthostatic hypotension. Manage constipation proactively.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicated
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicated
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-entacapone-levodopa Major
- Asenapine transdermal + Carbidopa-entacapone-levodopa Major
Frequently asked questions
Can I take Benzhydrocodone / acetaminophen with Carbidopa-entacapone-levodopa?
MediHelp rates the interaction as moderate. Benzhydrocodone / acetaminophen and Carbidopa-entacapone-levodopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids can cause sedation and orthostatic hypotension, and levodopa can add somnolence and hypotension. Constipation from opioids may also reduce levodopa absorption.
How serious is the interaction between Benzhydrocodone / acetaminophen and Carbidopa-entacapone-levodopa?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective opioid dose and monitor for sedation and orthostatic hypotension. Manage constipation proactively.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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