Drug interactions
Benzhydrocodone / acetaminophen + Darifenacin
Severity: Moderate
Benzhydrocodone / acetaminophen and Darifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzhydrocodone is converted to hydrocodone, which is partly metabolized by CYP2D6 and CYP3A4. Darifenacin is a modest CYP2D6 inhibitor so effects on hydrocodone are likely small, but both drugs reduce gut motility, so constipation and urinary retention may be additive.
What this interaction means in plain words
Benzhydrocodone / acetaminophen and Darifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on gastrointestinal and urinary smooth muscle, with minor CYP2D6 inhibition by darifenacin.
What to do
Monitor for constipation, urinary retention and sedation, and use a bowel regimen as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Darifenacin
Frequently asked questions
Can I take Benzhydrocodone / acetaminophen with Darifenacin?
MediHelp rates the interaction as moderate. Benzhydrocodone / acetaminophen and Darifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benzhydrocodone is converted to hydrocodone, which is partly metabolized by CYP2D6 and CYP3A4. Darifenacin is a modest CYP2D6 inhibitor so effects on hydrocodone are likely small, but both drugs reduce gut motility, so constipation and urinary retention may be additive.
How serious is the interaction between Benzhydrocodone / acetaminophen and Darifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for constipation, urinary retention and sedation, and use a bowel regimen as needed.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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