Drug interactions
Benzhydrocodone / acetaminophen + Dextroamphetamine
Severity: Moderate
Benzhydrocodone / acetaminophen and Dextroamphetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphetamines enhance serotonergic and noradrenergic transmission, and opioids may have additive serotonergic effects. Serotonin syndrome is possible, though uncommon with this opioid. Stimulants can also mask opioid sedation.
What this interaction means in plain words
Benzhydrocodone / acetaminophen and Dextroamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects, with opposing CNS effects on sedation.
What to do
Monitor for agitation, tremor, hyperreflexia, sweating and fever, especially at initiation or dose increases. Stop the combination and treat supportively if serotonin syndrome is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Benzhydrocodone / acetaminophen with Dextroamphetamine?
MediHelp rates the interaction as moderate. Benzhydrocodone / acetaminophen and Dextroamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphetamines enhance serotonergic and noradrenergic transmission, and opioids may have additive serotonergic effects. Serotonin syndrome is possible, though uncommon with this opioid. Stimulants can also mask opioid sedation.
How serious is the interaction between Benzhydrocodone / acetaminophen and Dextroamphetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, hyperreflexia, sweating and fever, especially at initiation or dose increases. Stop the combination and treat supportively if serotonin syndrome is suspected.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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