Drug interactions
Benzhydrocodone / acetaminophen + Diazepam
Severity: Major
Benzhydrocodone / acetaminophen and Diazepam: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzodiazepines combined with opioids can cause profound sedation, respiratory depression, coma and death, and this is a boxed warning for opioid products. Benzhydrocodone is a hydrocodone prodrug, so the risk matches other opioids.
What this interaction means in plain words
Benzhydrocodone / acetaminophen and Diazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression from GABA-A potentiation and mu-opioid agonism.
What to do
Reserve concurrent use for patients without alternatives, using the lowest doses and shortest duration. Monitor for sedation and respiratory depression and consider naloxone availability.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Diazepam
- Calcium / magnesium / potassium / sodium oxybates + Diazepam Contraindicated
- Alfentanil + Diazepam Major
- Alprazolam + Diazepam Major
- Amobarbital + Diazepam Major
- Belladonna and opium + Diazepam Major
- Brexanolone + Diazepam Major
Frequently asked questions
Can I take Benzhydrocodone / acetaminophen with Diazepam?
MediHelp rates the interaction as major. Benzhydrocodone / acetaminophen and Diazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Benzodiazepines combined with opioids can cause profound sedation, respiratory depression, coma and death, and this is a boxed warning for opioid products. Benzhydrocodone is a hydrocodone prodrug, so the risk matches other opioids.
How serious is the interaction between Benzhydrocodone / acetaminophen and Diazepam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve concurrent use for patients without alternatives, using the lowest doses and shortest duration. Monitor for sedation and respiratory depression and consider naloxone availability.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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