Drug interactions
Benzhydrocodone / acetaminophen + Lamotrigine
Severity: Moderate
Benzhydrocodone / acetaminophen and Lamotrigine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids and lamotrigine both cause CNS depression. Together they may increase drowsiness, dizziness and psychomotor impairment, and the opioid adds a risk of respiratory depression.
What this interaction means in plain words
Benzhydrocodone / acetaminophen and Lamotrigine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects.
What to do
Use the lowest effective opioid dose and monitor for sedation and respiratory depression. Counsel the patient about driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lamotrigine
Frequently asked questions
Can I take Benzhydrocodone / acetaminophen with Lamotrigine?
MediHelp rates the interaction as moderate. Benzhydrocodone / acetaminophen and Lamotrigine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids and lamotrigine both cause CNS depression. Together they may increase drowsiness, dizziness and psychomotor impairment, and the opioid adds a risk of respiratory depression.
How serious is the interaction between Benzhydrocodone / acetaminophen and Lamotrigine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective opioid dose and monitor for sedation and respiratory depression. Counsel the patient about driving and alcohol.
What other medicines interact with Lamotrigine?
MediHelp also lists interactions of Lamotrigine with, for example, Desogestrel-ethinyl estradiol, Divalproex, Dofetilide. The full list is on the Lamotrigine page.
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