Drug interactions
Benzhydrocodone / acetaminophen + Lorazepam
Severity: Major
Benzhydrocodone / acetaminophen and Lorazepam: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent use of a benzodiazepine and an opioid such as benzhydrocodone can cause profound sedation, respiratory depression, coma and death. This is a labeled boxed-warning interaction.
What this interaction means in plain words
Benzhydrocodone / acetaminophen and Lorazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression through GABA-A potentiation and mu-opioid receptor agonism.
What to do
Reserve concurrent use for patients without adequate alternatives, with the lowest effective doses and shortest duration. Monitor for sedation and respiratory depression and consider prescribing naloxone.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Lorazepam
- Alfentanil + Lorazepam Major
- Alprazolam + Lorazepam Major
- Amobarbital + Lorazepam Major
- Baclofen + Lorazepam Major
- Belladonna and opium + Lorazepam Major
- Brexanolone + Lorazepam Major
Frequently asked questions
Can I take Benzhydrocodone / acetaminophen with Lorazepam?
MediHelp rates the interaction as major. Benzhydrocodone / acetaminophen and Lorazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Concurrent use of a benzodiazepine and an opioid such as benzhydrocodone can cause profound sedation, respiratory depression, coma and death. This is a labeled boxed-warning interaction.
How serious is the interaction between Benzhydrocodone / acetaminophen and Lorazepam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve concurrent use for patients without adequate alternatives, with the lowest effective doses and shortest duration. Monitor for sedation and respiratory depression and consider prescribing naloxone.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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