Drug interactions
Benzphetamine + Buprenorphine
Severity: Minor
Benzphetamine and Buprenorphine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzphetamine is a sympathomimetic stimulant that might partly offset buprenorphine sedation, but the interaction is poorly defined. Neither drug's effect is reliably predictable in combination.
What this interaction means in plain words
Benzphetamine and Buprenorphine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible opposing pharmacodynamic effects on CNS arousal; mechanism is not established.
What to do
No dose adjustment is needed; monitor analgesic or opioid-treatment response and heart rate and blood pressure.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Buprenorphine
- Alvimopan + Buprenorphine Contraindicated
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Buprenorphine + Olanzapine / samidorphan Contraindicated
- Buprenorphine + Phenelzine Contraindicated
- Buprenorphine + Pimozide Contraindicated
- Buprenorphine + Thioridazine Contraindicated
Frequently asked questions
Can I take Benzphetamine with Buprenorphine?
MediHelp rates the interaction as minor. Benzphetamine and Buprenorphine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Benzphetamine is a sympathomimetic stimulant that might partly offset buprenorphine sedation, but the interaction is poorly defined. Neither drug's effect is reliably predictable in combination.
How serious is the interaction between Benzphetamine and Buprenorphine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor analgesic or opioid-treatment response and heart rate and blood pressure.
What other medicines interact with Buprenorphine?
MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan. The full list is on the Buprenorphine page.
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