Drug interactions
Benzphetamine + Clemastine
Severity: Minor
Benzphetamine and Clemastine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clemastine causes sedation while benzphetamine is a sympathomimetic anorectic that stimulates the CNS, so their effects may partly oppose each other. The net result is unpredictable, and stimulant effects may mask drowsiness without removing the impairment.
What this interaction means in plain words
Benzphetamine and Clemastine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing pharmacodynamic effects: H1 antihistamine sedation versus sympathomimetic CNS stimulation.
What to do
No dose change is usually needed. Ask the patient about drowsiness, palpitations and insomnia, and do not rely on the stimulant to offset sedation when driving.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clemastine
Frequently asked questions
Can I take Benzphetamine with Clemastine?
MediHelp rates the interaction as minor. Benzphetamine and Clemastine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Clemastine causes sedation while benzphetamine is a sympathomimetic anorectic that stimulates the CNS, so their effects may partly oppose each other. The net result is unpredictable, and stimulant effects may mask drowsiness without removing the impairment.
How serious is the interaction between Benzphetamine and Clemastine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Ask the patient about drowsiness, palpitations and insomnia, and do not rely on the stimulant to offset sedation when driving.
What other medicines interact with Clemastine?
MediHelp also lists interactions of Clemastine with, for example, Alfentanil, Benzhydrocodone / acetaminophen, Buprenorphine buccal. The full list is on the Clemastine page.
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