Drug interactions
Benzphetamine + Epinephrine
Severity: Moderate
Benzphetamine and Epinephrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzphetamine is a sympathomimetic anorectic, and combining it with epinephrine can produce additive increases in blood pressure and heart rate. Palpitations, arrhythmias and hypertensive responses are more likely in patients with cardiovascular disease.
What this interaction means in plain words
Benzphetamine and Epinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive sympathomimetic activity from direct adrenergic agonism and indirect norepinephrine release.
What to do
Monitor blood pressure, heart rate and ECG when epinephrine is given systemically. Use the lowest effective epinephrine dose in patients with hypertension or heart disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Benzphetamine with Epinephrine?
MediHelp rates the interaction as moderate. Benzphetamine and Epinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benzphetamine is a sympathomimetic anorectic, and combining it with epinephrine can produce additive increases in blood pressure and heart rate. Palpitations, arrhythmias and hypertensive responses are more likely in patients with cardiovascular disease.
How serious is the interaction between Benzphetamine and Epinephrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and ECG when epinephrine is given systemically. Use the lowest effective epinephrine dose in patients with hypertension or heart disease.
What other medicines interact with Epinephrine?
MediHelp also lists interactions of Epinephrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Epinephrine page.
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