Drug interactions
Benzphetamine + Hydralazine
Severity: Moderate
Benzphetamine and Hydralazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzphetamine is a sympathomimetic anorectic that can raise blood pressure and heart rate. This can oppose the antihypertensive effect of hydralazine, and hydralazine-induced reflex tachycardia may be additive with the stimulant effect.
What this interaction means in plain words
Benzphetamine and Hydralazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Sympathomimetic-mediated vasoconstriction and increased cardiac output counteract hydralazine vasodilation.
What to do
Monitor blood pressure and heart rate when the two are combined. Adjust the antihypertensive regimen or reconsider the anorectic if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Bretylium + Hydralazine Moderate
Frequently asked questions
Can I take Benzphetamine with Hydralazine?
MediHelp rates the interaction as moderate. Benzphetamine and Hydralazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benzphetamine is a sympathomimetic anorectic that can raise blood pressure and heart rate. This can oppose the antihypertensive effect of hydralazine, and hydralazine-induced reflex tachycardia may be additive with the stimulant effect.
How serious is the interaction between Benzphetamine and Hydralazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when the two are combined. Adjust the antihypertensive regimen or reconsider the anorectic if control is lost.
What other medicines interact with Hydralazine?
MediHelp also lists interactions of Hydralazine with, for example, Amifostine, Aceclofenac, Acemetacin. The full list is on the Hydralazine page.
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