Drug interactions
Benzphetamine + Olanzapine
Severity: Moderate
Benzphetamine and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzphetamine is a sympathomimetic anorectic whose stimulant effects oppose olanzapine's sedation, and the two have opposing effects on appetite and weight. Antipsychotics may also reduce the anorectic effect, while stimulants can worsen psychosis.
What this interaction means in plain words
Benzphetamine and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic opposition between dopamine and serotonin antagonism and sympathomimetic stimulation.
What to do
Monitor mental status for worsening psychosis or agitation and check heart rate and blood pressure. Consider a non-stimulant approach to weight management in patients taking olanzapine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Frequently asked questions
Can I take Benzphetamine with Olanzapine?
MediHelp rates the interaction as moderate. Benzphetamine and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benzphetamine is a sympathomimetic anorectic whose stimulant effects oppose olanzapine's sedation, and the two have opposing effects on appetite and weight. Antipsychotics may also reduce the anorectic effect, while stimulants can worsen psychosis.
How serious is the interaction between Benzphetamine and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor mental status for worsening psychosis or agitation and check heart rate and blood pressure. Consider a non-stimulant approach to weight management in patients taking olanzapine.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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