Drug interactions
Benztropine + Umeclidinium bromide / vilanterol inhaled
Severity: Moderate
Benztropine and Umeclidinium bromide / vilanterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Umeclidinium is an inhaled antimuscarinic, and benztropine adds systemic anticholinergic burden. This may cause dry mouth, urinary retention, constipation, tachycardia or worsening of narrow-angle glaucoma.
What this interaction means in plain words
Benztropine and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects.
What to do
Monitor for anticholinergic effects and urinary or ocular symptoms, and use the lowest effective benztropine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benztropine
- Benztropine + Memantine-donepezil Major
- Abobotulinumtoxina + Benztropine Moderate
- Amantadine + Benztropine Moderate
- Amitriptyline + Benztropine Moderate
- Amoxapine + Benztropine Moderate
- Atropine iv / + Benztropine Moderate
Frequently asked questions
Can I take Benztropine with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as moderate. Benztropine and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Umeclidinium is an inhaled antimuscarinic, and benztropine adds systemic anticholinergic burden. This may cause dry mouth, urinary retention, constipation, tachycardia or worsening of narrow-angle glaucoma.
How serious is the interaction between Benztropine and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects and urinary or ocular symptoms, and use the lowest effective benztropine dose.
What other medicines interact with Benztropine?
MediHelp also lists interactions of Benztropine with, for example, Memantine-donepezil, Abobotulinumtoxina, Amantadine. The full list is on the Benztropine page.
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