Drug interactions
Betaxolol + Butabarbital
Severity: Moderate
Betaxolol and Butabarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce hepatic enzymes and can lower plasma levels of betaxolol, which is partly hepatically metabolized. This may reduce beta-blocker effect on blood pressure or heart rate.
What this interaction means in plain words
Betaxolol and Butabarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturate induction of hepatic CYP enzymes increases betaxolol metabolism.
What to do
Monitor blood pressure and heart rate when starting or stopping butabarbital and increase the betaxolol dose if needed. Reassess the dose after the barbiturate is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Betaxolol
- Acebutolol + Betaxolol Major
- Aldesleukin + Betaxolol Major
- Amifostine + Betaxolol Major
- Amiodarone + Betaxolol Major
- Atenolol-chlorthalidone + Betaxolol Major
- Atenolol + Betaxolol Major
Frequently asked questions
Can I take Betaxolol with Butabarbital?
MediHelp rates the interaction as moderate. Betaxolol and Butabarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates induce hepatic enzymes and can lower plasma levels of betaxolol, which is partly hepatically metabolized. This may reduce beta-blocker effect on blood pressure or heart rate.
How serious is the interaction between Betaxolol and Butabarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or stopping butabarbital and increase the betaxolol dose if needed. Reassess the dose after the barbiturate is discontinued.
What other medicines interact with Betaxolol?
MediHelp also lists interactions of Betaxolol with, for example, Acebutolol, Aldesleukin, Amifostine. The full list is on the Betaxolol page.
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