Drug interactions
Betaxolol + Carbenoxolone
Severity: Moderate
Betaxolol and Carbenoxolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbenoxolone has mineralocorticoid-like activity causing sodium retention, hypertension and hypokalemia. This can oppose the antihypertensive effect of betaxolol, and hypokalemia adds arrhythmia risk.
What this interaction means in plain words
Betaxolol and Carbenoxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Carbenoxolone inhibits 11-beta-hydroxysteroid dehydrogenase, causing sodium and fluid retention that antagonizes antihypertensive therapy.
What to do
Monitor blood pressure and serum potassium during combined use. Consider an alternative to carbenoxolone if hypertension or hypokalemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Betaxolol
- Acebutolol + Betaxolol Major
- Aldesleukin + Betaxolol Major
- Amifostine + Betaxolol Major
- Amiodarone + Betaxolol Major
- Atenolol-chlorthalidone + Betaxolol Major
- Atenolol + Betaxolol Major
Frequently asked questions
Can I take Betaxolol with Carbenoxolone?
MediHelp rates the interaction as moderate. Betaxolol and Carbenoxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbenoxolone has mineralocorticoid-like activity causing sodium retention, hypertension and hypokalemia. This can oppose the antihypertensive effect of betaxolol, and hypokalemia adds arrhythmia risk.
How serious is the interaction between Betaxolol and Carbenoxolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and serum potassium during combined use. Consider an alternative to carbenoxolone if hypertension or hypokalemia develops.
What other medicines interact with Betaxolol?
MediHelp also lists interactions of Betaxolol with, for example, Acebutolol, Aldesleukin, Amifostine. The full list is on the Betaxolol page.
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