Drug interactions
Betaxolol + Cevimeline
Severity: Moderate
Betaxolol and Cevimeline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cevimeline is a muscarinic agonist that can slow heart rate and conduction. Combined with a beta blocker such as betaxolol, conduction disturbances and bradycardia may occur. Cevimeline labeling advises caution in patients taking beta blockers.
What this interaction means in plain words
Betaxolol and Cevimeline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Betaxolol belongs to Cardiovascular; Cevimeline belongs to Miscellaneous.
Why it happens
Additive pharmacodynamic effects on cardiac conduction from muscarinic stimulation and beta-adrenergic blockade.
What to do
Monitor heart rate and ECG in patients with conduction disease when starting cevimeline. Avoid the combination in those with significant bradycardia or AV block.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Betaxolol and Cevimeline, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Betaxolol
- Acebutolol + Betaxolol Major
- Aldesleukin + Betaxolol Major
- Amifostine + Betaxolol Major
- Amiodarone + Betaxolol Major
- Atenolol-chlorthalidone + Betaxolol Major
- Atenolol + Betaxolol Major
Other interactions of Cevimeline
- Amitriptyline + Cevimeline Moderate
- Atenolol-chlorthalidone + Cevimeline Moderate
- Atenolol + Cevimeline Moderate
- Atropine + Cevimeline Moderate
- Bethanechol + Cevimeline Moderate
- Bisoprolol + Cevimeline Moderate
Frequently asked questions
Can I take Betaxolol with Cevimeline?
MediHelp rates the interaction as moderate. Betaxolol and Cevimeline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cevimeline is a muscarinic agonist that can slow heart rate and conduction. Combined with a beta blocker such as betaxolol, conduction disturbances and bradycardia may occur. Cevimeline labeling advises caution in patients taking beta blockers.
How serious is the interaction between Betaxolol and Cevimeline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG in patients with conduction disease when starting cevimeline. Avoid the combination in those with significant bradycardia or AV block.
What other medicines interact with Betaxolol?
MediHelp also lists interactions of Betaxolol with, for example, Acebutolol, Aldesleukin, Amifostine. The full list is on the Betaxolol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
