Drug interactions
Betaxolol + Fenbufen
Severity: Moderate
Betaxolol and Fenbufen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as fenbufen can reduce the antihypertensive effect of beta-blockers by inhibiting prostaglandin synthesis and causing sodium and fluid retention. The effect is more evident with prolonged use.
What this interaction means in plain words
Betaxolol and Fenbufen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of vasodilatory prostaglandins and renal sodium retention antagonizes beta-blocker blood pressure lowering.
What to do
Monitor blood pressure when fenbufen is used regularly and adjust antihypertensive therapy as required. Use the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Betaxolol
- Acebutolol + Betaxolol Major
- Aldesleukin + Betaxolol Major
- Amifostine + Betaxolol Major
- Amiodarone + Betaxolol Major
- Atenolol-chlorthalidone + Betaxolol Major
- Atenolol + Betaxolol Major
Frequently asked questions
Can I take Betaxolol with Fenbufen?
MediHelp rates the interaction as moderate. Betaxolol and Fenbufen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as fenbufen can reduce the antihypertensive effect of beta-blockers by inhibiting prostaglandin synthesis and causing sodium and fluid retention. The effect is more evident with prolonged use.
How serious is the interaction between Betaxolol and Fenbufen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when fenbufen is used regularly and adjust antihypertensive therapy as required. Use the lowest effective NSAID dose for the shortest time.
What other medicines interact with Betaxolol?
MediHelp also lists interactions of Betaxolol with, for example, Acebutolol, Aldesleukin, Amifostine. The full list is on the Betaxolol page.
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