Drug interactions
Betaxolol + Phenoxybenzamine
Severity: Moderate
Betaxolol and Phenoxybenzamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenoxybenzamine causes irreversible alpha blockade and marked vasodilation. With betaxolol, hypotension and reflex responses are enhanced, and orthostatic symptoms are likely.
What this interaction means in plain words
Betaxolol and Phenoxybenzamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive blood pressure lowering from alpha blockade and beta blockade.
What to do
Monitor blood pressure and heart rate, titrate doses slowly, and in pheochromocytoma start the beta blocker only after adequate alpha blockade.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Betaxolol
- Acebutolol + Betaxolol Major
- Aldesleukin + Betaxolol Major
- Amifostine + Betaxolol Major
- Amiodarone + Betaxolol Major
- Atenolol-chlorthalidone + Betaxolol Major
- Atenolol + Betaxolol Major
Frequently asked questions
Can I take Betaxolol with Phenoxybenzamine?
MediHelp rates the interaction as moderate. Betaxolol and Phenoxybenzamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenoxybenzamine causes irreversible alpha blockade and marked vasodilation. With betaxolol, hypotension and reflex responses are enhanced, and orthostatic symptoms are likely.
How serious is the interaction between Betaxolol and Phenoxybenzamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, titrate doses slowly, and in pheochromocytoma start the beta blocker only after adequate alpha blockade.
What other medicines interact with Betaxolol?
MediHelp also lists interactions of Betaxolol with, for example, Acebutolol, Aldesleukin, Amifostine. The full list is on the Betaxolol page.
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