Drug interactions
Betaxolol + Pindolol
Severity: Major
Betaxolol and Pindolol: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combined beta-blockers add to heart rate and blood pressure lowering, risking bradycardia, AV block and hypotension. Pindolol's partial agonist activity does not eliminate this risk.
What this interaction means in plain words
Betaxolol and Pindolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic beta-adrenergic blockade.
What to do
Avoid duplicate beta-blockade and use one agent. If both are used, monitor heart rate, blood pressure and ECG.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Betaxolol
- Acebutolol + Betaxolol Major
- Aldesleukin + Betaxolol Major
- Amifostine + Betaxolol Major
- Amiodarone + Betaxolol Major
- Atenolol-chlorthalidone + Betaxolol Major
- Atenolol + Betaxolol Major
Frequently asked questions
Can I take Betaxolol with Pindolol?
MediHelp rates the interaction as major. Betaxolol and Pindolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combined beta-blockers add to heart rate and blood pressure lowering, risking bradycardia, AV block and hypotension. Pindolol's partial agonist activity does not eliminate this risk.
How serious is the interaction between Betaxolol and Pindolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicate beta-blockade and use one agent. If both are used, monitor heart rate, blood pressure and ECG.
What other medicines interact with Betaxolol?
MediHelp also lists interactions of Betaxolol with, for example, Acebutolol, Aldesleukin, Amifostine. The full list is on the Betaxolol page.
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