Drug interactions
Betaxolol + Propranolol
Severity: Major
Betaxolol and Propranolol: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are beta-blockers, so using them together duplicates therapy without added benefit. It increases the risk of bradycardia, hypotension, AV block and fatigue.
What this interaction means in plain words
Betaxolol and Propranolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Betaxolol belongs to Cardiovascular; Propranolol belongs to Cardiovascular.
Why it happens
Therapeutic duplication with additive beta-adrenergic blockade.
What to do
Avoid combining two beta-blockers and use a single agent at an optimized dose. If both have been taken, stop one and monitor heart rate and blood pressure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Other interactions of Betaxolol
- Acebutolol + Betaxolol Major
- Aldesleukin + Betaxolol Major
- Amifostine + Betaxolol Major
- Amiodarone + Betaxolol Major
- Atenolol-chlorthalidone + Betaxolol Major
- Atenolol + Betaxolol Major
Frequently asked questions
Can I take Betaxolol with Propranolol?
MediHelp rates the interaction as major. Betaxolol and Propranolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are beta-blockers, so using them together duplicates therapy without added benefit. It increases the risk of bradycardia, hypotension, AV block and fatigue.
How serious is the interaction between Betaxolol and Propranolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two beta-blockers and use a single agent at an optimized dose. If both have been taken, stop one and monitor heart rate and blood pressure.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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