Drug interactions
Betaxolol + Sildenafil
Severity: Moderate
Betaxolol and Sildenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sildenafil causes systemic vasodilation, and betaxolol lowers blood pressure through beta-1 blockade. Together they can produce a greater fall in blood pressure than either drug alone, with possible dizziness or symptomatic hypotension.
What this interaction means in plain words
Betaxolol and Sildenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Betaxolol belongs to Cardiovascular; Sildenafil belongs to Genitourinary.
Why it happens
Additive blood pressure lowering through PDE5-mediated vasodilation combined with beta-blocker antihypertensive effects.
What to do
Start sildenafil at the lowest dose in patients on betaxolol and check blood pressure and orthostatic symptoms after initiation. Advise patients to rise slowly and report fainting or lightheadedness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sildenafil
- Amyl nitrite + Sildenafil Contraindicated
- Atazanavir + Sildenafil Contraindicated
- Cobicistat + Sildenafil Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Sildenafil Contraindicated
- Glyceryl trinitrate pr + Sildenafil Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
Other interactions of Betaxolol
- Acebutolol + Betaxolol Major
- Aldesleukin + Betaxolol Major
- Amifostine + Betaxolol Major
- Amiodarone + Betaxolol Major
- Atenolol-chlorthalidone + Betaxolol Major
- Atenolol + Betaxolol Major
Frequently asked questions
Can I take Betaxolol with Sildenafil?
MediHelp rates the interaction as moderate. Betaxolol and Sildenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sildenafil causes systemic vasodilation, and betaxolol lowers blood pressure through beta-1 blockade. Together they can produce a greater fall in blood pressure than either drug alone, with possible dizziness or symptomatic hypotension.
How serious is the interaction between Betaxolol and Sildenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start sildenafil at the lowest dose in patients on betaxolol and check blood pressure and orthostatic symptoms after initiation. Advise patients to rise slowly and report fainting or lightheadedness.
What other medicines interact with Sildenafil?
MediHelp also lists interactions of Sildenafil with, for example, Amyl nitrite, Atazanavir, Cobicistat. The full list is on the Sildenafil page.
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