Drug interactions
Betaxolol + Yohimbe
Severity: Moderate
Betaxolol and Yohimbe: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbine is an alpha-2 antagonist that increases sympathetic outflow, raising blood pressure and heart rate. Beta blockers may blunt the tachycardia but also oppose the intended sympathetic effects. Yohimbe can reduce the antihypertensive effect of betaxolol.
What this interaction means in plain words
Betaxolol and Yohimbe can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism between yohimbine-induced sympathetic activation and beta blockade.
What to do
Avoid yohimbe in patients treated for hypertension or heart disease. Monitor blood pressure if it is used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Betaxolol
- Acebutolol + Betaxolol Major
- Aldesleukin + Betaxolol Major
- Amifostine + Betaxolol Major
- Amiodarone + Betaxolol Major
- Atenolol-chlorthalidone + Betaxolol Major
- Atenolol + Betaxolol Major
Frequently asked questions
Can I take Betaxolol with Yohimbe?
MediHelp rates the interaction as moderate. Betaxolol and Yohimbe can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Yohimbine is an alpha-2 antagonist that increases sympathetic outflow, raising blood pressure and heart rate. Beta blockers may blunt the tachycardia but also oppose the intended sympathetic effects. Yohimbe can reduce the antihypertensive effect of betaxolol.
How serious is the interaction between Betaxolol and Yohimbe?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid yohimbe in patients treated for hypertension or heart disease. Monitor blood pressure if it is used.
What other medicines interact with Betaxolol?
MediHelp also lists interactions of Betaxolol with, for example, Acebutolol, Aldesleukin, Amifostine. The full list is on the Betaxolol page.
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