Drug interactions
Betrixaban + Carvedilol
Severity: Major
Betrixaban and Carvedilol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carvedilol inhibits P-glycoprotein and can increase betrixaban exposure, raising the risk of bleeding. Betrixaban labeling recommends a reduced dose with P-gp inhibitors.
What this interaction means in plain words
Betrixaban and Carvedilol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Inhibition of P-glycoprotein-mediated efflux of betrixaban increases its plasma concentration.
What to do
Reduce betrixaban to the labeled dose for P-gp inhibitors (80 mg once, then 40 mg daily) and monitor for bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Betrixaban and Carvedilol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Carvedilol
Frequently asked questions
Can I take Betrixaban with Carvedilol?
MediHelp rates the interaction as major. Betrixaban and Carvedilol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carvedilol inhibits P-glycoprotein and can increase betrixaban exposure, raising the risk of bleeding. Betrixaban labeling recommends a reduced dose with P-gp inhibitors.
How serious is the interaction between Betrixaban and Carvedilol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce betrixaban to the labeled dose for P-gp inhibitors (80 mg once, then 40 mg daily) and monitor for bleeding.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
