Drug interactions
Betrixaban + Fenoprofen
Severity: Major
Betrixaban and Fenoprofen: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs raise bleeding risk, since fenoprofen impairs platelet function and can injure the gastric mucosa while betrixaban inhibits factor Xa. The combination increases the likelihood of clinically significant gastrointestinal and other bleeding. Neither drug raises the other's blood level.
What this interaction means in plain words
Betrixaban and Fenoprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic hemostatic impairment: NSAID antiplatelet effect and mucosal injury with factor Xa inhibition.
What to do
Avoid the combination where possible and use paracetamol for pain. If it is unavoidable, use the shortest NSAID course with gastroprotection and monitor for bleeding and hemoglobin.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Frequently asked questions
Can I take Betrixaban with Fenoprofen?
MediHelp rates the interaction as major. Betrixaban and Fenoprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs raise bleeding risk, since fenoprofen impairs platelet function and can injure the gastric mucosa while betrixaban inhibits factor Xa. The combination increases the likelihood of clinically significant gastrointestinal and other bleeding. Neither drug raises the other's blood level.
How serious is the interaction between Betrixaban and Fenoprofen?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use paracetamol for pain. If it is unavoidable, use the shortest NSAID course with gastroprotection and monitor for bleeding and hemoglobin.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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