Drug interactions
Betrixaban + Ketorolac
Severity: Major
Betrixaban and Ketorolac: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents impair hemostasis, and ketorolac also carries a risk of GI ulceration, so the combination raises the risk of serious bleeding. Ketorolac is contraindicated in patients at high risk of bleeding and with concurrent anticoagulants in many labels.
What this interaction means in plain words
Betrixaban and Ketorolac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic effects: betrixaban inhibits factor Xa while ketorolac inhibits platelet function and damages GI mucosa.
What to do
Avoid the combination where possible and use a non-NSAID analgesic. If unavoidable, use the shortest course and monitor closely for bleeding and hemoglobin changes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Frequently asked questions
Can I take Betrixaban with Ketorolac?
MediHelp rates the interaction as major. Betrixaban and Ketorolac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents impair hemostasis, and ketorolac also carries a risk of GI ulceration, so the combination raises the risk of serious bleeding. Ketorolac is contraindicated in patients at high risk of bleeding and with concurrent anticoagulants in many labels.
How serious is the interaction between Betrixaban and Ketorolac?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use a non-NSAID analgesic. If unavoidable, use the shortest course and monitor closely for bleeding and hemoglobin changes.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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