Drug interactions
Betrixaban + Ulipristal
Severity: Moderate
Betrixaban and Ulipristal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ulipristal may inhibit P-glycoprotein and increase betrixaban exposure. Higher betrixaban levels raise the risk of bleeding. With single-dose ulipristal the effect is likely short-lived.
What this interaction means in plain words
Betrixaban and Ulipristal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
P-glycoprotein inhibition by ulipristal reduces efflux of betrixaban, raising its plasma concentrations.
What to do
Monitor for signs of bleeding during and shortly after ulipristal use. Follow the betrixaban label dose reduction for P-gp inhibitors if prolonged coadministration is expected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Frequently asked questions
Can I take Betrixaban with Ulipristal?
MediHelp rates the interaction as moderate. Betrixaban and Ulipristal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ulipristal may inhibit P-glycoprotein and increase betrixaban exposure. Higher betrixaban levels raise the risk of bleeding. With single-dose ulipristal the effect is likely short-lived.
How serious is the interaction between Betrixaban and Ulipristal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding during and shortly after ulipristal use. Follow the betrixaban label dose reduction for P-gp inhibitors if prolonged coadministration is expected.
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