Drug interactions
Bictegravir + Ferrous gluconate
Severity: Moderate
Bictegravir and Ferrous gluconate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iron binds bictegravir in the gut and can lower its exposure when taken fasting. Reduced levels may lead to loss of HIV virologic suppression or resistance.
What this interaction means in plain words
Bictegravir and Ferrous gluconate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Iron cations chelate bictegravir in the gastrointestinal tract, reducing absorption.
What to do
Take bictegravir and iron together with food, or take bictegravir at least 2 hours before iron when fasting. Do not take iron within 2 hours before bictegravir on an empty stomach.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ferrous gluconate
Frequently asked questions
Can I take Bictegravir with Ferrous gluconate?
MediHelp rates the interaction as moderate. Bictegravir and Ferrous gluconate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iron binds bictegravir in the gut and can lower its exposure when taken fasting. Reduced levels may lead to loss of HIV virologic suppression or resistance.
How serious is the interaction between Bictegravir and Ferrous gluconate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take bictegravir and iron together with food, or take bictegravir at least 2 hours before iron when fasting. Do not take iron within 2 hours before bictegravir on an empty stomach.
What other medicines interact with Ferrous gluconate?
MediHelp also lists interactions of Ferrous gluconate with, for example, Ciprofloxacin, Acetohydroxamic acid, Aluminum hydroxide. The full list is on the Ferrous gluconate page.
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