Drug interactions
Bictegravir + Metformin-sitagliptin
Severity: Moderate
Bictegravir and Metformin-sitagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bictegravir inhibits renal OCT2 and MATE1, which clear metformin. Metformin levels rise, increasing the risk of gastrointestinal effects and, rarely, lactic acidosis, especially with renal impairment.
What this interaction means in plain words
Bictegravir and Metformin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of OCT2 and MATE1-mediated renal tubular secretion of metformin by bictegravir.
What to do
Monitor glycemic control and renal function, and limit the metformin dose if needed when starting or stopping bictegravir. Take extra care in patients with reduced eGFR.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-sitagliptin
Frequently asked questions
Can I take Bictegravir with Metformin-sitagliptin?
MediHelp rates the interaction as moderate. Bictegravir and Metformin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bictegravir inhibits renal OCT2 and MATE1, which clear metformin. Metformin levels rise, increasing the risk of gastrointestinal effects and, rarely, lactic acidosis, especially with renal impairment.
How serious is the interaction between Bictegravir and Metformin-sitagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control and renal function, and limit the metformin dose if needed when starting or stopping bictegravir. Take extra care in patients with reduced eGFR.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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