Drug interactions
Bictegravir + Selenium
Severity: Minor
Bictegravir and Selenium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Polyvalent cations can chelate bictegravir in the gut and reduce its absorption, risking loss of virologic suppression. The effect is established for aluminium, magnesium, calcium and iron, but selenium is not a typical polyvalent cation supplement and its effect is likely small.
What this interaction means in plain words
Bictegravir and Selenium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible chelation of bictegravir by selenium-containing supplements in the gastrointestinal tract, reducing absorption.
What to do
Take bictegravir at least 2 hours before selenium supplements, or take both together with food if separation is not possible.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Selenium
- Alendronate + Selenium Moderate
- Eltrombopag + Selenium Moderate
- Ibandronate + Selenium Moderate
- Penicillamine + Selenium Moderate
- Risedronate + Selenium Moderate
- Baloxavir marboxil + Selenium Minor
Frequently asked questions
Can I take Bictegravir with Selenium?
MediHelp rates the interaction as minor. Bictegravir and Selenium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Polyvalent cations can chelate bictegravir in the gut and reduce its absorption, risking loss of virologic suppression. The effect is established for aluminium, magnesium, calcium and iron, but selenium is not a typical polyvalent cation supplement and its effect is likely small.
How serious is the interaction between Bictegravir and Selenium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take bictegravir at least 2 hours before selenium supplements, or take both together with food if separation is not possible.
What other medicines interact with Selenium?
MediHelp also lists interactions of Selenium with, for example, Alendronate, Eltrombopag, Ibandronate. The full list is on the Selenium page.
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