Drug interactions
Bisoprolol + Butabarbital
Severity: Minor
Bisoprolol and Butabarbital: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce hepatic enzymes and may lower bisoprolol exposure, since part of its clearance is hepatic. This could reduce heart rate and blood pressure control. Additive sedation can also occur.
What this interaction means in plain words
Bisoprolol and Butabarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Induction of CYP3A4-mediated metabolism of bisoprolol by the barbiturate.
What to do
Monitor heart rate and blood pressure when butabarbital is started or stopped, and increase the bisoprolol dose if control is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bisoprolol
Frequently asked questions
Can I take Bisoprolol with Butabarbital?
MediHelp rates the interaction as minor. Bisoprolol and Butabarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Barbiturates induce hepatic enzymes and may lower bisoprolol exposure, since part of its clearance is hepatic. This could reduce heart rate and blood pressure control. Additive sedation can also occur.
How serious is the interaction between Bisoprolol and Butabarbital?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when butabarbital is started or stopped, and increase the bisoprolol dose if control is lost.
What other medicines interact with Bisoprolol?
MediHelp also lists interactions of Bisoprolol with, for example, Aldesleukin, Amifostine, Amiodarone. The full list is on the Bisoprolol page.
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