Drug interactions
Bisoprolol + Butalbital
Severity: Minor
Bisoprolol and Butalbital: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate that may induce hepatic enzymes and modestly lower bisoprolol levels. Clinical impact is expected to be small, since bisoprolol is also cleared by the kidney.
What this interaction means in plain words
Bisoprolol and Butalbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Induction of hepatic metabolism of bisoprolol by the barbiturate.
What to do
Monitor heart rate and blood pressure when butalbital is started or stopped, and adjust the bisoprolol dose only if the response changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bisoprolol
Frequently asked questions
Can I take Bisoprolol with Butalbital?
MediHelp rates the interaction as minor. Bisoprolol and Butalbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Butalbital is a barbiturate that may induce hepatic enzymes and modestly lower bisoprolol levels. Clinical impact is expected to be small, since bisoprolol is also cleared by the kidney.
How serious is the interaction between Bisoprolol and Butalbital?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when butalbital is started or stopped, and adjust the bisoprolol dose only if the response changes.
What other medicines interact with Bisoprolol?
MediHelp also lists interactions of Bisoprolol with, for example, Aldesleukin, Amifostine, Amiodarone. The full list is on the Bisoprolol page.
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