Drug interactions
Bisoprolol + Fexinidazole
Severity: Major
Bisoprolol and Fexinidazole: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole can prolong the QT interval and cause bradycardia, and bisoprolol slows heart rate. Together they may raise the risk of serious bradyarrhythmia and torsades de pointes.
What this interaction means in plain words
Bisoprolol and Fexinidazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive bradycardic effects, with QT prolongation from fexinidazole raising arrhythmic risk.
What to do
Avoid the combination where possible, or hold bisoprolol during fexinidazole if clinically safe. Obtain an ECG and electrolytes and monitor heart rate if coadministered.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Bisoprolol
Frequently asked questions
Can I take Bisoprolol with Fexinidazole?
MediHelp rates the interaction as major. Bisoprolol and Fexinidazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fexinidazole can prolong the QT interval and cause bradycardia, and bisoprolol slows heart rate. Together they may raise the risk of serious bradyarrhythmia and torsades de pointes.
How serious is the interaction between Bisoprolol and Fexinidazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or hold bisoprolol during fexinidazole if clinically safe. Obtain an ECG and electrolytes and monitor heart rate if coadministered.
What other medicines interact with Bisoprolol?
MediHelp also lists interactions of Bisoprolol with, for example, Aldesleukin, Amifostine, Amiodarone. The full list is on the Bisoprolol page.
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