Drug interactions
Bisoprolol + Metaproterenol
Severity: Moderate
Bisoprolol and Metaproterenol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bisoprolol is a beta-1 selective blocker that can blunt the bronchodilator effect of metaproterenol, a beta-agonist, particularly at higher doses when selectivity is lost. In patients with asthma or COPD this may cause bronchospasm and poor response to rescue therapy.
What this interaction means in plain words
Bisoprolol and Metaproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism at beta-adrenergic receptors, with loss of cardioselectivity at higher bisoprolol doses.
What to do
Use the lowest effective bisoprolol dose and monitor respiratory status and bronchodilator response. Consider a non-beta-blocker alternative in patients with significant reactive airway disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bisoprolol
Frequently asked questions
Can I take Bisoprolol with Metaproterenol?
MediHelp rates the interaction as moderate. Bisoprolol and Metaproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bisoprolol is a beta-1 selective blocker that can blunt the bronchodilator effect of metaproterenol, a beta-agonist, particularly at higher doses when selectivity is lost. In patients with asthma or COPD this may cause bronchospasm and poor response to rescue therapy.
How serious is the interaction between Bisoprolol and Metaproterenol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective bisoprolol dose and monitor respiratory status and bronchodilator response. Consider a non-beta-blocker alternative in patients with significant reactive airway disease.
What other medicines interact with Bisoprolol?
MediHelp also lists interactions of Bisoprolol with, for example, Aldesleukin, Amifostine, Amiodarone. The full list is on the Bisoprolol page.
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